First I thought I’d use the theme as a game look making a RTS where different bacteria battle it out.
Then I thought of using it as a game atmosphere and background story, where you are a contraceptive inside the womb, fighting off sperm and such(but it’s been done to death)
Then I thought of it like a gameplay objective, a game where you shrink worlds in order to collect them and put them in a museum
Or a gameplay mechanic, where you shrink to get into places you can’t enter otherwise.
Not sure what I will go with yet.